Endocrine Abstracts

Introduction: With the advent of specific gene targeted therapies for advanced thyroid cancers it has become important that molecular genetic testing is requested to identify patients suitable for these treatments, for example with BRAF, RET or NTRK inhibitors. We investigated the proportion of patients with advanced thyroid cancer in a specialist thyroid cancer clinic who had undergone appropriate testing.Participants and Method...

Background: The COMMODITY12 is a telemedicine system designed for continuous monitoring of diabetes type 1 (DM1) and DM2, as well as the cardiovascular comorbidities. The system has been created in collaboration of nine European academic and industrial partners under FP7 (www.commodity12.eu).Aim: The aim of this study was to assess clinical utility of the COMMODITY12 system in DM2 patients, under a design of a mini...

Introduction: Thyroid hemiagenesis (TH) is characterised by congenital absence of one thyroid lobe.Aim: To assess possible association between TH and concomitant alterations of other structures derived from pharyngeal apparatus, which might potentially impact calcium-phosphate balance.Materials and methods: Studied group: 20 patients with TH. Control group: 20 subjects with bilobed thyroid, matched for age and gender. Serum concent...

Laparoscopic surgery of adrenal tumours is widely used because of its high effectiveness, patients safety and relatively low cost. Current indications to adrenalectomy of oncological and endocrinological origin are highly accepted. However there is still lack of perfect clinical tool identifying malignant lesions. In everyday practice clinicians rely on low specific features, especially considering larger nonsecretory lesions to surgery.To show the lands...

Introduction: Irisin is a newly discovered adipo-myokine, that has a significant influence on body metabolism. Available data about this peptide is still insufficient. The aim of the study is to provide some initial information about body distribution of irisin in rats.Methods: The studied group consisted of 27 10-week-old female Wistar rats, which received intraperitoneally ~0.7 mcCi of iodine-125 labeled irisin. The studied rats were divided on five su...

Introduction: GH therapy in children with normal GH peak in stimulation tests (GHST) is still a matter of discussion. Recently, GH deficiency (GHD) has been defined as secondary IGF1 deficiency (IGFD), however GHST still remain the main procedure in diagnosing GHD.The aim of present study was to compare GH therapy effectiveness in the patients with normal results of GHST (normGH) and with isolated partial GHD (pGHD), with respect to IGF-I secretion befor...

Introduction.: The diagnosis of GH deficiency (GHD) is based on decreased GH peak in stimulating tests (GHST). Recently, GHD has been re-defined as secondary IGF1 deficiency (IGFD). However, IGF1 may increase during GH therapy in the patients with normal GH peak in GHST, suggesting a diagnosis of non-primary IGFD (npIGFD).The aim of the study was to compare GH therapy effectiveness in children with GHD and with npIGFD (responding to GH administration des...

Introduction: In majority of patients with childhood-onset GH deficiency (GHD), normalisation of GH secretion at the attainment of final height (FH) is observed. However, different criteria for GHD diagnosis may be considered.The aim of the study was to compare the auxological and hormonal data of the patients with persistent and transient GHD, diagnosed according to different criteria.Patients and methods: The analysis comprised 1...

Indications to GH therapy in children with short stature are still a matter of discussion.We compared first-year response to GH therapy in 80 children (62 boys, 18 girls), age 12.7±2.4 years (mean±S.D.) with different disorders of GH secretion. In all the patients nocturnal GH secretion assessed during 3 h after falling asleep was decreased (<10 ng/ml). In 40 children GH deficiency (GHD) was diagnosed on the ground of decreas...

Normal thyroid hormone secretion (or appropriate L-thyroxin substitution) is necessary for the optimal effect GH administration on growing rate. The decrease of free thyroxin (FT4) levels at GH therapy onset was reported in several studies.The aim of our study was to assess the incidence of hypothyroidism (HT) during the initial phase of GH administration in previously euthyroid children with GH deficiency (GHD) and to compare t...